Misleading Recent Papers on Statin Drugs in Peer-Reviewed Medical Journals

Joel M. Kauffman, Ph.D.

ABSTRACT

Three papers on clinical trials with statin drugs, published in 2004–2006, imply that the observed improvement in selected trial endpoints result from gross reductions in serum total cholesterol (TC) and cholesterol carried by low-density lipoprotein (LDL-C), despite evidence to the contrary, which was not cited in these papers.

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Virtually Continuous Euglycemia for 5 Yr in a Labile Juvenile-onset Diabetic Patient Under Noninvasive Closed-Loop Control

Reprinted from DIABETES CARE, VOL. 3, NO. 1, JANUARY-FEBRUARY 1980 Copyright 1980 by the American Diabetes Association, Inc.

RICHARD K. BERNSTEIN

The author, diabetic for 33 yr, has used a novel technique for maintaining blood glucose (BG) in the 60— 120 mg/dl range and HhA1~ in the 3.95— 6.4% range, thereby lowering serum triglycerides from 200+ to 29 mg/dl, cholesterol from 250+ to 130 mg/dl, and insulin dosage from 80 to 25 U/day.

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Some Long-term Sequelae of Poorly Controlled Diabetes that are Frequently Undiagnosed, Misdiagnosed, or Mistreated

By Richard K. Bernstein, MD, FACE, FACN, CWS

Many years of scientific studies of both animals and humans have provided overwhelming evidence that the long-term adverse sequelae of diabetes are caused by elevated blood glucose (BG). A recent meta analysis of studies of over 95,000 individuals demonstrated that even within BG ranges generally considered normal, the risk of cardiovascular events increases exponentially with blood sugar. Elevated BG adversely affects every tissue of the body, with the possible exception of hair.

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Health promotion when the ‘vaccine’ does not work

Abstract
The epidemics of obesity, metabolic syndrome and type 2 diabetes have worsened over the past decades. During this time our preventive and therapeutic approach (the ‘vaccine’), consisting of a low-fat diet and exercise, has remained fundamentally unchanged. A case is made that these conditions are inter-related and may be caused by a single underlying factor related to the carbohydrate content of diet. Read more Health promotion when the ‘vaccine’ does not work

The case for low carbohydrate diets in diabetes management

Abstract

A low fat, high carbohydrate diet in combination with regular exercise is the traditional recommendation for treating diabetes. Compliance with these lifestyle modifications is less than satisfactory, however, and a high carbohydrate diet raises postprandial plasma glucose and insulin secretion, thereby increasing risk of CVD, hypertension, dyslipidemia, obesity and diabetes. Moreover, the current epidemic of diabetes and obesity has been, over the past three decades, accompanied by a significant decrease in fat consumption and an increase in carbohydrate consumption. This apparent failure of the traditional diet, from a public health point of view, indicates that alternative dietary approaches are needed. Because carbohydrate is the major secretagogue of insulin, some form of carbohydrate restriction is a prima facie candidate for dietary control of diabetes. Evidence from various randomized controlled trials in recent years has convinced us that such diets are safe and effective, at least in short-term. These data show low carbohydrate diets to be comparable or better than traditional low fat high carbohydrate diets for weight reduction, improvement in the dyslipidemia of diabetes and metabolic syndrome as well as control of blood pressure, postprandial glycemia and insulin secretion. Furthermore, the ability of low carbohydrate diets to reduce triglycerides and to increase HDL is of particular importance. Resistance to such strategies has been due, in part, to equating it with the popular Atkins diet. However, there are many variations and room for individual physician planning. Some form of low carbohydrate diet, in combination with exercise, is a viable option for patients with diabetes. However, the extreme reduction of carbohydrate of popular diets (<30 g/day) cannot be recommended for a diabetic population at this time without further study. On the other hand, the dire objections continually raised in the literature appear to have very little scientific basis. Whereas it is traditional to say that more work needs to be done, the same is true of the assumed standard low fat diets which have an ambiguous record at best. We see current trends in the national dietary recommendations as a positive sign and an appropriate move in the right direction.

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Dietary Carbohydrate, Protein and Fat for People With Glucose Metabolism Disorders. Just What is Optimal?

Dietary Carbohydrate, Protein and Fat for People With
Glucose Metabolism Disorders. Just What is
Optimal?

A collection of research, studies, science, facts, and opinions.

Dr Katharine Morrison.
February 2005.

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