Clinical Studies on Chromium Picolinate Supplementation in Diabetes Mellitus—A Review


Chromium (Cr) picolinate (CrPic) is a widely used nutritional supplement for optimal insulin function. A relationship among Cr status, diabetes, and associated pathologies has been established. Virtually all trials using CrPic supplementation for subjects with diabetes have demonstrated beneficial effects. Thirteen of 15 clinical studies (including 11 randomized, controlled studies) involving a total of 1,690 subjects (1,505 in CrPic group) reported significant improvement in at least one outcome of glycemic control. All 15 studies showed salutary effects in at least one parameter of diabetes management, including dyslipidemia. Positive outcomes from CrPic supplementation included reduced blood glucose, insulin, cholesterol, and triglyceride levels and reduced requirements for hypoglycemic medication. The greater bioavailability of CrPic compared with other forms of Cr (e.g., niacin-bound Cr or CrCl3) may explain its comparatively superior efficacy in glycemic and lipidemic control. The pooled data from studies using CrPic supplementation for type 2 diabetes mellitus subjects show substantial reductions in hyperglycemia and hyperinsulinemia, which equate to a reduced risk for disease complications. Collectively, the data support the safety and therapeutic value of CrPic for the management of cholesterolemia and hyperglycemia in subjects with diabetes.

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Arguments In Favor Of Ketogenic Diets

Many negative comments have been made about the use of ketogenic diets (KDs) and experts today
believe that the best way to lose weight is by cutting back on calories, chiefly in the form of fat. The
international consensus is that carbohydrates are the basis of the food pyramid for a healthy diet.
However, this review will clarify that low-carbohydrate diets are, from a practical and physiological point
of view, a much more effective way of losing weight. It is also argued that such diets provide metabolic
advantages, for example: they help to preserve muscle mass, reduce appetite, diminish metabolic
efficiency, induce metabolic activation of thermogenesis and favor increased fat loss and even a greater
reduction in calories. These diets are also healthier because they promote a non-atherogenic lipid profile,
lower blood pressure and decrease resistance to insulin with an improvement in blood levels of glucose
and insulin. Low-carbohydrate diets should therefore be used to prevent and treat type II diabetes and
cardiovascular problems. Such diets also have neurological and antineoplastic benefits and diet-induced
ketosis is not associated with metabolic acidosis, nor do such diets alter kidney, liver or heart functions.

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Panel suggests that dietary guidelines stop warning about cholesterol in food – Harvard Health Blog – Harvard Health Publications

The scientific advisory panel for the 2015 Dietary Guidelines for Americans may drop the recommendation to limit foods high in cholesterol.

Source: Panel suggests that dietary guidelines stop warning about cholesterol in food – Harvard Health Blog – Harvard Health Publications