Press Releases: The Biliary Tree of Life

Researchers at the Diabetes Research Institute (DRI) have described a network of stem cells in the biliary tree, liver, and pancreas – and they are proposing to consider it as a framework for understanding liver and pancreas regeneration after extensive or chronic injuries.

Taking it one step further, they suggest that these stem cells should be considered for the study and treatment of diseases that affect these organs – such as type 1 diabetes.

Origins and evolution of the Western diet: health implications for the 21st century


There is growing awareness that the profound changes in the envi- ronment (eg, in diet and other lifestyle conditions) that began with the introduction of agriculture and animal husbandry ?10 000 y ago occurred too recently on an evolutionary time scale for the human genome to adjust. In conjunction with this discordance between our ancient, genetically determined biology and the nutritional, cultural, and activity patterns of contemporary Western populations, many of the so-called diseases of civilization have emerged. In particular, food staples and food-processing procedures introduced during the Neolithic and Industrial Periods have fundamentally altered 7 cru- cial nutritional characteristics of ancestral hominin diets: 1) glyce- mic load, 2) fatty acid composition, 3) macronutrient composition, 4) micronutrient density, 5) acid-base balance, 6) sodium-potassium ratio, and 7) fiber content. The evolutionary collision of our ancient genome with the nutritional qualities of recently introduced foods may underlie many of the chronic diseases of Western civilization. Am J Clin Nutr 2005;81:341–54.

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Dietary carbohydrate restriction in type 2 diabetes mellitus and metabolic syndrome: time for a critical appraisal


Current nutritional approaches to metabolic syndrome and type 2 diabetes generally rely on reductions in dietary fat. The success of such approaches has been limited and therapy more generally relies on pharmacology. The argument is made that a re-evaluation of the role of carbohydrate restriction, the historical and intuitive approach to the problem, may provide an alternative and possibly superior dietary strategy. The rationale is that carbohydrate restriction improves glycemic control and reduces insulin fluctuations which are primary targets. Experiments are summarized showing that carbohydrate-restricted diets are at least as effective for weight loss as low-fat diets and that substitution of fat for carbohydrate is generally beneficial for risk of cardiovascular disease. These beneficial effects of carbohydrate restriction do not require weight loss. Finally, the point is reiterated that carbohydrate restriction improves all of the features of metabolic syndrome.

DOWNLOAD: Study by 24 Doctors and Researchs ADA Rebuttal for Stancy on Low Carb

A Low Carbohydrate Diet in Type 1 Diabetes: Clinical Experience – A Brief Report

Jørgen Vesti Nielsen, Eva Jönsson, Anette Ivarsson

Department of Medicine, Blekingesjukhuset, Karlshamn, Sweden


Due to failure to achieve control twenty-two patients with type 1 diabetes with sympto- matic fluctuating blood glucose started on a diet limited to 70-90 g carbohydrates per day and were taught to match the insulin doses accordingly. The caloric requirements were covered by an increased intake of protein and fat. The purpose was to reduce the blood glucose fluctuations, the rate of hypoglycaemia and to improve HbA1c.

DOWNLOAD: Low-carb in type 1 diabetes