Comparison with ancestral diets suggests dense acellular carbohydrates promote an inflammatory microbiota, and may be the primary dietary cause of leptin resistance and obesity

Comparison with ancestral diets suggests dense acellular carbohydrates promote an inflammatory microbiota, and may be the primary dietary cause of leptin resistance and obesity

Abstract: A novel hypothesis of obesity is suggested by consideration of diet-related inflammation and evolutionary medicine. The obese homeostatically guard their elevated weight. In rodent models of high-fat diet-induced obesity, leptin resistance is seen initially at vagal afferents, blunting the actions of satiety mediators, then centrally, with gastrointestinal bacterial-triggered SOCS3 signaling implicated. In humans, dietary fat and fructose elevate systemic lipopolysaccharide, while dietary glucose also strongly activates SOCS3 signaling. Crucially however, in humans, low-carbohydrate diets spontaneously decrease weight in a way that low-fat diets do not. Furthermore, nutrition transition patterns and the health of those still eating diverse ancestral diets with abundant food suggest that neither glycemic index, altered fat, nor carbohydrate intake can be intrinsic causes of obesity, and that human energy homeostasis functions well without Westernized foods containing flours, sugar, and refined fats. Due to being made up of cells, virtually all “ancestral foods” have markedly lower carbohydrate densities than flour- and sugar-containing foods, a property quite independent of glycemic index. Thus the “forgotten organ” of the gastrointestinal microbiota is a prime candidate to be influenced by evolutionarily unprecedented postprandial luminal carbohydrate concentrations. The present hypothesis suggests that in parallel with the bacterial effects of sugars on dental and periodontal health, acellular flours, sugars, and processed foods produce an inflammatory microbiota via the upper gastrointestinal tract, with fat able to effect a “double hit” by increasing systemic absorption of lipopolysaccharide. This model is consistent with a broad spectrum of reported dietary phenomena. A diet of grain-free whole foods with carbohydrate from cellular tubers, leaves, and fruits may produce a gastrointestinal microbiota consistent with our evolutionary condition, potentially explaining the exceptional macronutrient-independent metabolic health of non-Westernized populations, and the apparent efficacy of the modern “Paleolithic” diet on satiety and metabolism.

Keywords: carbohydrate density, metabolic syndrome, nutrition transition, Paleolithic diet

We Finally Know How Dogs Sniff Out Diabetes

For years, assistance dogs have been used to detect low blood sugar levels in their diabetic owners and warn of an impending hypoglycemia attack. Scientists have finally figured out how dogs are able to accomplish this feat—an insight that could lead to new medical sensors.

Source: We Finally Know How Dogs Sniff Out Diabetes

Therapeutic and prophylactic effects of crude honey on chronic seborrheic dermatitis and dandruff

Eur J Med Res. 2001 Jul 30;6(7):306-8.

Since seborrheic dermatitis can be a complication for many diabetics I thought I would pass along this interesting study on using RAW honey (I think using raw honey is a key distinction versus the regular stuff you might buy at the store).

Source: Therapeutic and prophylactic effects of crude honey on chronic seborrheic dermatitis and dandruff. – PubMed – NCBI

DIABECELL

http://www.lctglobal.com/products/diabecell

DIABECELL® is a breakthrough cell therapy that has the potential to change the lives of the millions of people worldwide with type 1 diabetes.

Type 1 diabetes usually requires life-long treatment with regular insulin injections.

DIABECELL is an insulin-producing cell product derived from pigs for the treatment of type 1 diabetes. These islet cells are self-regulating and efficiently secrete insulin in the patient’s body.

The treatment involves introducing encapsulated pig cells into the patient’s abdomen in a simple laparoscopic procedure. Living Cell Technologies’ unique proprietary encapsulation technology prevents the islet cells from being attacked by the patient’s immune system. This allows the use of cell therapies without the need for co-treatment with drugs that suppress the immune system, which often have negative side effects.

Press Releases: The Biliary Tree of Life

Researchers at the Diabetes Research Institute (DRI) have described a network of stem cells in the biliary tree, liver, and pancreas – and they are proposing to consider it as a framework for understanding liver and pancreas regeneration after extensive or chronic injuries.

Taking it one step further, they suggest that these stem cells should be considered for the study and treatment of diseases that affect these organs – such as type 1 diabetes.

http://www.diabetesresearch.org/Biliary-Tree-of-Life?srctid=1&erid=2611923&trid=12cc53cb-674b-4735-b667-345cc3c43aff