DIABECELL

http://www.lctglobal.com/products/diabecell

DIABECELL® is a breakthrough cell therapy that has the potential to change the lives of the millions of people worldwide with type 1 diabetes.

Type 1 diabetes usually requires life-long treatment with regular insulin injections.

DIABECELL is an insulin-producing cell product derived from pigs for the treatment of type 1 diabetes. These islet cells are self-regulating and efficiently secrete insulin in the patient’s body.

The treatment involves introducing encapsulated pig cells into the patient’s abdomen in a simple laparoscopic procedure. Living Cell Technologies’ unique proprietary encapsulation technology prevents the islet cells from being attacked by the patient’s immune system. This allows the use of cell therapies without the need for co-treatment with drugs that suppress the immune system, which often have negative side effects.

Press Releases: The Biliary Tree of Life

Researchers at the Diabetes Research Institute (DRI) have described a network of stem cells in the biliary tree, liver, and pancreas – and they are proposing to consider it as a framework for understanding liver and pancreas regeneration after extensive or chronic injuries.

Taking it one step further, they suggest that these stem cells should be considered for the study and treatment of diseases that affect these organs – such as type 1 diabetes.

http://www.diabetesresearch.org/Biliary-Tree-of-Life?srctid=1&erid=2611923&trid=12cc53cb-674b-4735-b667-345cc3c43aff

A Low Carbohydrate Diet in Type 1 Diabetes: Clinical Experience – A Brief Report

Jørgen Vesti Nielsen, Eva Jönsson, Anette Ivarsson

Department of Medicine, Blekingesjukhuset, Karlshamn, Sweden

ABSTRACT

Due to failure to achieve control twenty-two patients with type 1 diabetes with sympto- matic fluctuating blood glucose started on a diet limited to 70-90 g carbohydrates per day and were taught to match the insulin doses accordingly. The caloric requirements were covered by an increased intake of protein and fat. The purpose was to reduce the blood glucose fluctuations, the rate of hypoglycaemia and to improve HbA1c.

DOWNLOAD: Low-carb in type 1 diabetes

The Effects of a Low-Carbohydrate Regimen on Glycemic Control and Serum Lipids in Diabetes Mellitus

DANIEL F. O’NEILL,1 ERIC C. WESTMAN, M.D., M.H.S.,1 and RICHARD K. BERNSTEIN, M.D.2

ABSTRACT

The Diabetes Complications and Control Trial (DCCT) established that diabetic complica- tions could be reduced by improvement in glycemic control. The ideal diabetes treatment protocol would maintain blood glucose levels in normal ranges without resulting in frequent hypoglycemia. Because several studies suggest an inverse relationship between carbohydrate consumption and the level of glycemic control, the effects of an intensive treatment program, which included dietary carbohydrate restriction, are examined in this paper. A chart review was performed of 30 patients who self-reported the consumption of 30 g of carbohydrate daily, followed a strict insulin regimen, monitored blood glucose levels at least four times daily, and had follow-up clinical visits or phone calls with their physician. For both type I and type II diabetics, there were significant improvements in glycemic control and mean fast- ing lipid profiles at follow-up. The mean hemoglobin A1c decreased by 27.8% from 7.9 to 5.7 (p < 0.001). The LDL cholesterol decreased by 16.5%, from 155.4 to 129.7 mg/dL (p = 0.004). The triglycerides decreased by 31.1%, from 106.8 to 73.6 mg/dL (p = 0.005). The HDL cholesterol increased by 43.3%, from 50.4 to 72.2 mg/dL (p < 0.001). The cholesterol/HDL ratio decreased by 31.5%, from 4.99 to 3.42 (p < 0.001). A carbohydrate-restricted regimen improved glycemic control and lipid profiles in selected motivated patients. Therefore, further investigation of the effects of this protocol on treating diabetes mellitus should be considered. Additionally, the reduction of insulin afforded by this diet could theoretically lead to a reduction in hypo- glycemic events.

DOWNLOAD: ONeill2003

Virtually Continuous Euglycemia for 5 Yr in a Labile Juvenile-onset Diabetic Patient Under Noninvasive Closed-Loop Control

Reprinted from DIABETES CARE, VOL. 3, NO. 1, JANUARY-FEBRUARY 1980 Copyright 1980 by the American Diabetes Association, Inc.

RICHARD K. BERNSTEIN

The author, diabetic for 33 yr, has used a novel technique for maintaining blood glucose (BG) in the 60— 120 mg/dl range and HhA1~ in the 3.95— 6.4% range, thereby lowering serum triglycerides from 200+ to 29 mg/dl, cholesterol from 250+ to 130 mg/dl, and insulin dosage from 80 to 25 U/day.

DOWNLOAD: whitepaper

How To: Keep Healthy with Diabetes

This section is for everyone.



Overview

Meal Planning

Self-monitoring of Blood Glucose

Use of Insulin and Diabetes Medications

Foot Care

Urine Testing for Ketones

Annual Health Checks

You need to be confident about…

 

Overview

The Joslin Diabetes Centre have a check list so you can see what sort of things you need to know to look after yourself with diabetes. This list covers type one and type two diabetes. For each heading I will list what we have already covered on this course and what we will be covering in more depth in the Type One Section *

There is a considerable overlap between both types of diabetes. To start with most people with insulin dependent diabetes diagnosed in childhood or young adulthood are  not overweight or insulin resistant. As time goes on this may change so Type Ones would benefit from reading the earlier sections to see if any of it applies to them. The majority of the carb counting methods have also already been covered in the Metabolic and Type 2 section.

For type twos who start off on diet or oral medications they may find that after  a while this is no longer sufficient to maintain normal blood sugars. You may benefit by reading on to find out how to deal with insulin now or in the future.

If you don’t feel really confident about any of the things I have listed please take advantage of some of the books and internet resources in the help sections. It is important that you know what to do ahead of any emergency developing so please contact your diabetes support team for further personal training.

 

MEAL PLANNING

Your own meal plan
know how carbs, proteins* and fats affect the body
special foods and occasions
dining out
portion control
label reading
how to fit in treats*
alcohol*

 

SELF MONITORING OF BLOOD SUGAR

blood glucose goals
how to use the meter
monitoring schedule*
storing supplies*
interpreting blood glucose values and making decisions in diabetes treatment plan*

USE OF INSULIN AND DIABETES MEDICATIONS

Action and side effects of medication*
timing and schedule*
insulin injection techniques*
storage, refrigeration and disposal of supplies*
what to do if you miss a dose*

EXERCISE

What type, how long, how hard, how often and when.*
snacking adjustments*
preventing high and low blood sugars*

KNOWLEDGE OF HIGH AND LOW BLOOD GLUCOSE

Factors that cause high and low blood glucose*
symptoms*
how to treat*
when to call a healthcare provider*
how to prevent*

FOOT CARE

daily foot care*
emergency treatment for cuts, sores and abrasions.
how to do a proper foot exam*
proper footwear

URINE TESTING FOR KETONES

When and how to check for ketones*
What ketones mean*
When to call a doctor*

YOUR HEALTH TEAM WILL DO THESE ANNUAL CHECKS AND TESTS

A1C ( 2-4 times a year)*
kidney function*
cholesterol, ldl, hdl, triglycerides*
foot exam*
eye exam*
blood pressure*
general health check eg thyroid, tests for coeliac disease and anything relevant to you*

YOU NEED TO BE VERY CONFIDENT ABOUT…

Your own meal plan
The medication you are taking
Your glucose monitoring system
The treatment of high and low blood sugars
How to manage your sick days
Your risk factors for developing other health problems
Your foot care

 


Quick Quiz:
1. A test type twos should have done every six months is…
a Liver function and creatine kinase.
b Hbaic.
c Fasting lipids.
d Sex hormone binding globulin.

Have you got it?
1. You must have your hbaic checked every 3-6 months. If statins are being taken, fasting blood lipids, liver and creatine kinase levels may be taken episodically.

Where to Next?
Please all proceed to the How To: Safely Dispose of Needles and Other Sharps section.